Programme

• Sun
• Mon
• Tue
• Wed
• Thu
• Fri
• Sat

• Sunday, 26 March

  17:00-18:00	Arrival and registration
  18:00	Welcome ceremony Introduction to the school, general information, and assignment of students to Agora teams
  19:00	Welcome drinks followed by buffet dinner

• Monday, 27 March

  9:00-9:40	Richard Robitaille (Université de Montréal • Montreal, QC, Canada) Decoding the code: beyond the measurements of Ca2+ in glial cells [25 min + 10 min discussion]
  9:40-10:20	Alfonso Araque (University of Minnesota • Minneapolis, MN, USA) Stimulating neurons and astrocytes [25 min + 10 min discussion]
  10:20-10:40	Coffee break
  10:40-11:20	Amit Agarwal (Heidelberg University • Heidelberg, Germany) Astrocyte Ca2+ signals: analysis and interpretation [25 min + 10 min discussion]
  11:20-12:15	Student presentations [7 min + 3 min discussion each] Laura Baños Carrión (Valencia, Spain) Non-canonical autophagy processes in Lafora disease Luis Sánchez-Miranda Pajuelo (Madrid, Spain) Protein Kinase D1 regulates astrocyte maturation and mitochondrial biogenesis Eugenia Vivi (Regensburg, Germany) Astrocyte-mediated phagocytosis in mood and depressive-like disorders Mariagiovanna Di Chiano (Bari, Italy) Expression of the nuclear factor erythroid2-related factor2 in inflamed microglial cells which are treated with cell free bacterial culture supernatants previously in the context of neuroinflammation associated with multiple sclerosis Nikita Arnst (Padua, Italy) Quantitative microglia analysis reveals diverse morphologic responses in the 2-months-old B6.152H mice in the cortex and hippocampus
  12:15-12:30	Agora • Preparation (1)
  12:30-14:00	Lunch (and agora preparation)
  14:00-15:35	Student presentations [7 min + 3 min discussion each] Faezeh Ashouri (Madrid, Spain) Role of astrocytic GABAbRs in MDD Angel Baudon (Strasbourg, France) Central amygdala astrocytes oxytocin receptor Gαi pathway mediates behavioral adaptation in mice Ilknur Coban (Heidelberg, Germany) Alpha2a adrenergic receptors on astrocytes regulate neuropathic pain Alessandro Di Spiezio (Padua, Italy) Interaction between cholinergic and glutamatergic synaptic transmission at tripartite synapse in the pathophysiology of Alzheimer's disease Giulia Favetta (Padua, Italy) Dopamine signaling in striatal astrocytes Norma Angélica Rivera Villaseñor (Querétaro, Mexico) Astrocytes activity mediate the duration of working memory Martina Breccia (Milan, Italy) MeCP2 deficiency in astrocytes alters synaptogenesis: new insights on Rett syndrome
  15:35-16:15	Frank Kirchhoff (University of Saarland • Homburg, Germany) Promises and caveats of genetically modified mice in glia research [25 min + 10 min discussion]
  16:15-16:35	Coffee break
  16:35-17:15	Keith Murai (McGill University Health Centre • Montréal, QC, Canada) Embracing the molecular, structural, and functional diversity of astrocytes [25 min + 10 min discussion]
  17:15-18:15	Student presentations [7 min + 3 min discussion each] Elena Garcia Clave (Neuherberg, Germany) Dissecting the crosstalk between astrocytes and the melanocortin system in the control of energy homeostasis Caroline Léger (Paris, France) Role of astrocytes in maintaining energy balance and consequences of their adaptation to a high calorie diet Tommaso Dalla Tor (Bordeaux, France) In vivo imaging of CB1-dependent modulation of brain metabolism Andre Kirunda (Houston, TX, USA) In vivo two photon observation of astrocyte membrane potential fluctuations in primary visual cortex of anesthetized mice Josien Visser (Genoa, Italy) Mesoscale two-photon imaging of astrocytic calcium dynamics during multisensory perception
  20:00	Dinner

• Tuesday, 28 March

  09:00-10:15	Student presentations [7 min + 3 min discussion each] Giulia Dematteis (Novara, Italy) Mind the gap: a role for ER-mitochondria interaction in Alzheimer’s disease astrocytes cellular dysfunction Christiaan Huffels (Utrecht, The Netherlands) Amyloid-β plaques affect astrocyte kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice Giulia Puliatti (Rome, Italy) The astrocyte-mediated action of extracellular tau oligomers on synaptic function is due to the APP-dependent expression of the Glypican-4 receptor Micaela Zonta (Padua, Italy) Ca2+ signaling dysregulation in cortical astrocytes in the progression of Alzheimer’s disease: a new target to rescue synaptic plasticity deficits Agnès Chaperon (Paris, France) Glucocorticoid receptors in astrocytes regulate alpha-synuclein pathological actions impacting motor an non-moto symptomology of Parkinson's disease Bruna Da Silva Oliveira (Belo Horizonte, Brazil) Early nigrostriatal inflammation is associated with nonmotor symptoms in an experimental model of Parkinson's disease Shelby Hetzer (Cincinnati,OH, USA) Adolescent stress reduces severity of traumatic brain injury outcomes in the optic system chronically despite decreasing glial phagocytosis
  10:15-10:55	Gertrudis Perea (Cajal Institute CSIC • Madrid, Spain) Analysis of astrocytic impact beyond single synapses: modulation of neuronal networks [25 min + 10 min discussion]
  10:55-11:15	Coffee break
  11:15-12:10	Student presentations [7 min + 3 min discussion each] Marta Ornaghi (Berlin, Germany) Drebrin controls scar formation and astrocytes reactivity upon traumatic brain injury by regulating membrane trafficking Natalija Aleksejenko (Dublin, Ireland) Astrocytic microRNA control of blood brain barrier breakdown in epilepsy Alberto Melecchi (Pisa, Italy) Müller cell reactivity as an early event of retinal neurovascular breakdown in the DBA/2J mouse model of glaucoma Laura Kuil (Amsterdam, The Netherlands) Radiotherapy-induced cognitive impairment in cancer patients: is senescence involved, or is it glia? Cynthia Martin Jimenez (Atlanta, GE, USA) Tibolone ameliorates the lipotoxic effect of palmitic acid in normal human astrocytes
  12:10-12:50	Jaideep Bains (University of Calgary • Calgary, Canada) Astrocyte CB1 receptors and the transmission of stress [25 min + 10 min discussion]
  12:50-14:10	Lunch
  14:10-15:25	Student presentations [7 min + 3 min discussion each] Rachel Breton (Paris, France) A role for astrocytes in the visual cortex critical period Maria João Pereira (Leuven, Belgium) Unravelling the molecular mechanisms by which astrocytes promote neuroplasticity in adulthood Airi Watanabe (Montreal, Canada) Astrocytes in developing neocortical synaptic plasticity Sylvie Lahaie (Montreal, Canada) Characterization of hippocampal and cortical astrocytic primary cilia in CNS health and disease João Viana (Braga, Portugal) Astrocyte structural heterogeneity in the mouse hippocampus Zhenyang Sun (Toronto, Canada) Exploration of the structural vs. functional interdependence in anatomical and signaling interactions of astrocytes with cortical neuronal circuits
  15:25-16:05	Kerstin Lenk (Graz University of Technology • Graz, Austria) Computational astrocyte models at the single-cell level [25 min + 10 min discussion]
  16:05-18:05	Agora • Preparation (2) [with coffee]
  20:00	Pizza party

• Wednesday, 29 March

  9:00-9:40	Giovanni Marsicano (INSERM • Bordeaux, France) Behavioral analyses: data versus interpretations [25 min + 10 min discussion]
  9:40-10:20	Elly Hol (UMC Utrecht • Utrecht, The Netherlands) Human astrocytes: from omics to organoids [25 min + 10 min discussion]
  10:20-10:50	Coffee break
  10:50-11:30	Amit Agarwal (Heidelberg University • Heidelberg, Germany) Astrocytic adrenergic receptors in pain modulation [25 min + 10 min discussion]
  11:30-12:10	Frank Kirchhoff (University of Saarland • Homburg, Germany) Molecular and cellular signaling pathways between neurons and glial cells: sex matters! [25 min + 10 min discussion]
  12:10-13:30	Lunch
  14:00	Departure to Ravenna Sightseeing and guided tours, followed by dinner Return to Bertinoro after dinner

• Thursday, 30 March

  9:00-9:40	Keith Murai (McGill University Health Centre • Montréal, QC, Canada) Astrocyte nanoarchitecture in CNS health and disease [25 min + 10 min discussion]
  9:40-10:20	Gertrudis Perea (Cajal Institute CSIC • Madrid, Spain) Astrocyte-neuron signaling in prefrontal circuits: role in animal behavior [25 min + 10 min discussion]
  10:20-10:45	Coffee break
  10:45-11:25	Kerstin Lenk (Graz University of Technology • Graz, Austria) Computational astrocyte models at the network level [25 min + 10 min discussion]
  11:25-12:05	Alfonso Araque (University of Minnesota • Minneapolis, MN, USA) Scaling up tripartite synapses: from synapses to network and behavior [25 min + 10 min discussion]
  12:05-13:30	Lunch
  13:30-14:10	Giorgio Carmignoto (CNR Istituto di Neuroscienze • Padua, Italy) Multiple actions of astrocytes in the Ventral Tegmental Area [25 min + 10 min discussion]
  14:10-14:50	Giovanni Marsicano (INSERM • Bordeaux, France) CB1 receptors in astrocytes: quantity is not quality [25 min + 10 min discussion]
  14:50-18:00	Agora • Preparation (3) [with coffee]
  20:00	Dinner

• Friday, 31 March

  9:00-9:40	Jaideep Bains (University of Calgary • Calgary, Canada) Associative learning in hypothalamic astrocytes [25 min + 10 min discussion]
  9:40-10:20	Elly Hol (UMC Utrecht • Utrecht, The Netherlands) Reactive astrocytes and functional consequences in Alzheimer's disease [25 min + 10 min discussion]
  10:20-10:50	Coffee break
  10:50-11:30	Richard Robitaille (Université de Montréal • Montreal, QC, Canada) Glial cells at the neuromuscular junction as a therapeutic target in ALS [25 min + 10 min discussion]
  11:30-12:10	Giorgio Carmignoto (CNR Istituto di Neuroscienze • Padua, Italy) WE and I in research [25 min + 10 min discussion]
  12:10-13:30	Lunch
  13:30-16:00	Agora presentations [with coffee]
  16:00-16:30	General discussion, Concluding Remarks, Questionnaires
  20:00	Farewell Dinner

• Saturday, 1 April

  Departure